SportsLine's model has simulated Los Angeles vs. Arizona on Monday Night Football 10,000 times and revealed its MNF picks and predictions

The Los Angeles Chargers (3-2) are favored by just 1.5 points against the Arizona Cardinals (2-4) on Monday, October 21, 2024.NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 10:58

The 49ers have had several extra days of rest themselves — a condition in which Brock Purdy is 3-0 straight up in regular-season games when the spread is four points or less. The Chiefs’ league-leading pressure rate is challenged with Purdy’s 67 percent completion rate when under duress.