eLife10h
Heat Shock Factor Regulation of Antimicrobial Peptides Expression Suggests a Conserved Defense Mechanism Induced by Febrile Temperature in Arthropods
China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Guangzhou, China ...
eLife2d
Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling
Cell-cell interaction between neural crest-derived cells and mesoderm-derived cells determine cell fate of mesoderm-derived cell in tongue development through Hh signaling.
eLife2d
Negative cell cycle regulation by calcineurin is necessary for proper beta cell regeneration in zebrafish
Calcineurin fine tunes the balance between proliferation and differentiation of Notch-responsive progenitors in the pancreatic ducts to enable beta cell regeneration in zebrafish.
Opinion
eLife1dOpinion
Point of View: Being a PhD student in Morocco today
Early-career researchers in the Global South have to overcome obstacles that are not found in high-income countries, but in Morocco at least, the future is looking brighter than the past.
eLife3d
IFIT1 is rapidly evolving and exhibits disparate antiviral activities across 11 mammalian orders
This valuable report describes the changing antiviral activity of IFIT1 across mammals and in response to distinct viruses, likely as a result of past arms races. One of the main strengths of the ...
eLife3d
PD-1 negatively regulates helper T cell differentiation into Th2
This valuable study reports on a novel role of PD-1 in early T cell differentiation, showing that PD-1 stimulation impairs Th2 differentiation more effectively than that of Th1, with implications for ...
eLife3d
Low-dimensional olfactory signatures of fruit ripening and fermentation
This study demonstrates that plant and fruit volatiles can be organized according to a low-dimensional hyperbolic map, and that within this map exist trajectories that correspond to important ...
eLife3d
A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targets
A bioinformatics pipeline describes 390 putative, novel inhibitory receptors, to facilitate targeted therapeutic strategies for diverse immune cell types in cancer therapy.
eLife3d
Temporal dynamics analysis reveals that concurrent working memory load eliminates the Stroop effect through disrupting stimulus-response mapping
This important study investigates how working memory load influences the Stroop effect from a temporal dynamics perspective. Solid evidence is provided that the working memory load influences the ...
eLife2d
Pathogenic Huntingtin aggregates alter actin organization and cellular stiffness resulting in stalled clathrin mediated endocytosis
Aggregation of mutant forms of Huntingtin is the underlying feature of neurodegeneration observed in Huntington's disorder. In addition to neurons, cellular processes in non-neuronal cell types are ...
eLife3d
Menopausal hormone therapy and the female brain: leveraging neuroimaging and prescription registry data from the UK Biobank cohort
Menopausal hormone therapy (MHT) is generally thought to be neuroprotective, yet results have been inconsistent. Here, we present a comprehensive study of MHT use and brain characteristics in ...
eLife3d
Hierarchical cortical plasticity in congenital sight impairment
An anatomically defined retinotopy atlas was applied to the inflated cortical surface for each participant in order to delineate the borders of V1, V2 and V3, and also each degree of eccentricity up ...