Combining NFL picks and building NFL parlays is a common way to try to make a quick buck, but nailing NFL score predictions can be highly profitable. NFL matchups, potential game flow and NFL betting trends should all be taken into consideration before locking in Week 7 NFL game picks.

Week 6 was not a good week for underdogs. Only 3 of 14 covered the spread and 2 won straight up (SU). The Chicago Bears won in London as 1.5-point underdogs, the Cleveland Browns lost by 4 as 8-point

The Washington Commanders and Buffalo Bills are the two biggest favorites this week at ESPN BET, and are both shaping up as popular picks. However, if you want to avoid the chalk, ESPN Analytics and Mike Clay's model both recommend the Indianapolis Colts as an undervalued contrarian play.